mature b cell造句

• CR2 on mature B cells forms a complex with CD19 and CD81.
• If the maturing B cells strongly interact with these self antigens, they undergo death by apoptosis.
• Homozygous mutant mice had hyperalbuminemia, decreased mature B cell numbers and increased susceptibility to bacterial infection.
• On the other hand, immunoglobulin class switching causes heavy chain rearrangement of the mature B cell ..
• Surprisingly, pax5 conditional knock out mice allowed peripheral mature B cells to de-differentiate to early bone marrow progenitors.
• Then it recruits the body's natural defenses to attack and kill both malignant and normal mature B cells.
• CR2 on mature B cells form a complex with two other membrane proteins, CD19 and CD81 ( = TAPA-1 ).
• Na飗e mature B cells produce both IgM and IgD, which are the first two heavy chain segments in the immunoglobulin locus.
• Rituxan works by binding to a protein known as the CD20 antigen on the surface of mature B cells and B-cell tumors.
• Hairy cells are nearly mature B cells, which are activated clonal cells with signs of VH gene differentiation . or memory cells.
• BCMA is a tumor necrosis factor receptor family protein expressed on mature B cells and plasma cells and can be targeted on multiple myeloma.
• This behavior, and that fact that only mature B cells display the BLyS receptors, may provide the opportunity to kill B-cell lymphomas selectively, Dr . Haseltine said.
• XLA patients, however, are apparently immune to the Epstein-Barr virus ( EBV ), as they lack mature B cells ( and so HLA co-receptors ) needed for the viral infection.
• This protein is constitutively expressed in mature B cells, plasma cells and plasmacytoid dendritic cells, and in many other cells, it is only expressed as a response to stimuli from IFN pathway.
• Activated mature B cells also possess two other remarkable, RAG-independent phenomena of manipulating their own DNA : so-called class-switch recombination ( AKA isotype switching ) and somatic hypermutation ( AKA affinity maturation ).
• Unlike most chemotherapy agents, which kill cells unselectively, the radioactive BLyS would home in on the cancerous B cell and the mature B cells, he said; the patient's immune system would be reconstituted from the younger B cells.
• CD10 is found on non-T ALL cells, which derive from pre-B lymphocytes, and in germinal center-related non-Hodgkin lymphoma such as Burkitt lymphoma and follicular lymphoma, but not on leukemia cells or lymphomas, which originate in more mature B cells.
• On mature B cells, both IgM and IgD are co-expressed through long mRNA transcripts which undergo differential splicing; the transcript for IgM is produced when the VDJ exon is spliced to the C? exon, with polyadenylation at p ( A1 ).
• Comparing the DNA of B cells ( a type of white blood cell ) in embryonic and adult mice, he observed that genes in the mature B cells of the adult mice are moved around, recombined, and deleted to form the diversity of the variable region of antibodies.